A woman pulling a bar down on a weights machine, seen from behind.

Taking a GLP-1 medication?

Weight train. It’s not optional.

The medication takes the appetite away. Without strength training, a large share of what you lose can be muscle, not fat. 2 to 3 sessions of 30 minutes a week help protect it.

Why it matters

The medication can’t tell muscle from fat

GLP-1 medications work by taking the appetite away, so you eat far less. Your body then burns what it has, and it is not fussy about where that comes from. In the key trial of a GLP-1 medication, people lost 15% of their body weight over 68 weeks, and almost 10% of their lean mass went with it: about four kilos in every ten lost. Sources 1 and 2

Lean tissue is not all muscle (it includes water and organ tissue), but it is the part of weight loss nobody wants to lose: it keeps you strong, steady on your feet and burning energy at rest. Strength training is what helps protect it while the fat comes off. Source 3

15%

of body weight lost over 68 weeks

9.7%

of lean mass lost in the same time

4 in 10

kilos lost were lean tissue, not fat, on average

The STEP 1 trial, body-composition analysis: 140 people over 68 weeks (source 1).

Six reasons

Why weight training matters on a GLP-1

It keeps the muscle

The weight you lose should be fat. Resistance training has been shown to limit lean-mass loss during a calorie deficit, and the researchers who reviewed the GLP-1 trials recommend it alongside the medication for exactly that reason.

Sources 1 to 3

It protects your bones

Losing weight can thin bone. In a year-long trial, people on a GLP-1 medication who did not exercise lost bone density at the hip and spine; those who exercised as well kept theirs. Lifting loads the bones directly, which is what tells them to stay strong.

Sources 4 and 5

It protects your metabolism

Muscle burns energy even at rest. Lose it and your resting metabolism falls with it. Resistance training nudges resting energy use the other way, by roughly 100 calories a day on average across studies.

Source 6

Blood sugar and blood pressure

Strength training improves how your body handles blood sugar, and lowers blood pressure a little as well.

Sources 7 and 8

Strength, balance and mood

Stronger muscles mean easier stairs and steadier balance as you get older; exercise programmes that include strength work reduce falls in older people. And a lift in mood: resistance training reduces symptoms of low mood in clinical trials.

Sources 9 and 10

What lasts after the prescription

In the follow-up to the key GLP-1 trial, people regained two thirds of the weight within a year of stopping. In another trial, exercise helped people keep weight off after a diet, whether or not they were on the medication. The habit comes with you when the prescription ends.

Sources 11 and 12

What we offer

A tailored weights plan for anyone on weight-loss medication

You don’t need to have lifted a weight in your life. We start with a private consultation, then design a strength and resistance routine around you: your body, your fitness level, your goals, your week and your medical history. The exercises, weights, reps, sets and rest are all set for you, not copied from a one-size-fits-all plan off the internet.

The sessions are your own, done in your own time whenever the gym is open: not a class, and not personal training. They are short on purpose: 30 minutes, 2 to 3 times a week, is all we ask, and each one is planned to make the most of the time. That is also what the World Health Organization asks of every adult: muscle-strengthening work on two or more days a week. Source 13

  • A private consultation first, medical history included
  • A plan built for your body: exercises, weights, reps and rest
  • Planned around past injuries and mobility limits
  • Steps up as you get stronger, with room to ease off on low-energy days
  • 2 to 3 sessions of 30 minutes a week, in your own time
  • We don’t prescribe or advise on medication: that stays with your prescriber

All it takes

2 to 3

sessions a week

30

minutes a session

Included with membership: the plan costs nothing extra.

GPs, pharmacists and clinics

If you prescribe GLP-1 medication

“Stay active” is hard advice to act on when you have never set foot in a gym. We give your patients something specific: a structured strength plan built around them, 2 to 3 short sessions a week in their own time, in a small local gym, included with their membership.

The simplest referral is to point your patient to this page: they arrange their own consultation, so no patient details need to come to us. For anything else, email or ring us.

Questions

What people ask before they message us.

Do I need any experience?

No. You don’t need to have lifted a weight before. Everything starts at your level and builds from there.

What does it cost?

The plan is included with membership, so there is nothing extra to pay for it. Ask us which membership suits you; prices are on our Memberships page.

Is it personal training, or a class?

Neither. We design your plan at your consultation; the sessions are yours to do, in your own time, whenever the gym is open. If you have questions along the way, just ask.

What does a session involve?

30 minutes of strength and resistance work, planned to make the most of the time: often full-body, or pairing opposite muscle groups so one rests while the other works. The exercises, weights, reps, sets and rest are set for you and step up as you get stronger, and you can ease off on a low-energy day.

What if I have an injury or a medical condition?

Check with your doctor before you start, and tell us at your consultation. Your routine is planned around past injuries, mobility limits and your medical history, and avoids movements that aggravate joint pain. If your doctor has set any limits, bring them with you. Please don’t send medical details by WhatsApp or the contact form; we’ll go through them with you at your consultation.

Is it confidential?

Yes. Your consultation is private, and what you tell us is kept private and used only to plan your training. Nobody else needs to know why you’re training.

Should I tell my doctor?

Yes. Keep taking your medication exactly as prescribed, and let your prescriber know you’re starting a strength programme. We don’t prescribe, supply or advise on medication; we train you while you’re on it.

What about food?

Eating enough protein matters too, especially when your appetite is low. Ask about it at your consultation.

Sources

Where the facts come from

Every claim on this page is numbered to a published study or guideline. This page is general information about exercise, not medical advice. Myfitt does not prescribe, supply or advise on medication: keep taking yours as prescribed, and talk to your prescriber before starting a new exercise programme.

  1. 1 Wilding JPH and others. Impact of semaglutide on body composition in adults with overweight or obesity: exploratory analysis of the STEP 1 study. Journal of the Endocrine Society, 2021. Body weight down 15.0% and lean mass down 9.7% at 68 weeks. Read it
  2. 2 Locatelli JC and others. Incretin-based weight loss pharmacotherapy: can resistance exercise optimize changes in body composition? Diabetes Care, 2024. Recommends tailored resistance exercise alongside the medication. Read it
  3. 3 Binmahfoz A and others. Effect of resistance exercise on body composition, muscle strength and cardiometabolic health during dietary weight loss in people living with overweight or obesity: a systematic review and meta-analysis. BMJ Open Sport and Exercise Medicine, 2025. Resistance exercise protected against the loss of fat-free mass. Read it
  4. 4 Jensen SBK and others. Bone health after exercise alone, GLP-1 receptor agonist treatment, or combination treatment: a secondary analysis of a randomized clinical trial. JAMA Network Open, 2024. Read it
  5. 5 Benedetti MG and others. The effectiveness of physical exercise on bone density in osteoporotic patients. BioMed Research International, 2018. Weight-bearing and resistance exercise maintain bone density. Read it
  6. 6 MacKenzie-Shalders K and others. The effect of exercise interventions on resting metabolic rate: a systematic review and meta-analysis. Journal of Sports Sciences, 2020. Resistance exercise raised resting metabolic rate by about 96 kcal a day. Read it
  7. 7 Colberg SR and others. Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care, 2016. Read it
  8. 8 Cornelissen VA, Smart NA. Exercise training for blood pressure: a systematic review and meta-analysis. Journal of the American Heart Association, 2013. Read it
  9. 9 Sherrington C and others. Exercise for preventing falls in older people living in the community. Cochrane Database of Systematic Reviews, 2019. Read it
  10. 10 Gordon BR and others. Association of efficacy of resistance exercise training with depressive symptoms: meta-analysis and meta-regression analysis of randomized clinical trials. JAMA Psychiatry, 2018. Read it
  11. 11 Wilding JPH and others. Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension. Diabetes, Obesity and Metabolism, 2022. Two thirds of the lost weight regained a year after stopping. Read it
  12. 12 Lundgren JR and others. Healthy weight loss maintenance with exercise, liraglutide, or both combined. New England Journal of Medicine, 2021. Read it
  13. 13 World Health Organization. Physical activity fact sheet: adults should do muscle-strengthening activities on two or more days a week. Read it

Keep what matters

Lose the fat. Keep the muscle.

Your medication helps you lose weight. Weight training helps you keep what matters. Call or WhatsApp us to find out more, or to arrange a confidential consultation.